Scientist, Large Scale RNA Production

Company: Disability Solutions
Location: Cambridge
Posted on: April 6, 2025

Job Description:

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.In the plan to create a new hub for mRNA-based vaccine discovery in Cambridge, we are building new laboratories that will be focused on the development of state-of-the-art methods that will be supporting deep product understanding, process and product development, as well as testing of pre-clinical and clinical samples for new mRNA-based vaccines.Scientist GSK RNA Vaccines CoE (RNA Research and Rapid Response Lab)The mRNA Research and Rapid Response Lab sits within the GSK RNA Vaccines Center of Excellence based out of GSK's Cambridge Park Drive facility in Boston, Massachusetts. The mRNA Research and Rapid Response Lab is responsible for generating and characterizing mRNA vaccine candidates against viral respiratory diseases. This team provides key molecular biology and cell biology support to mRNA vaccine discovery and development programs, and is also responsible for implementing new techniques and technologies to improve high throughput generation and screening of vaccine candidates, including high-throughput cloning, high-throughput RNA generation and high-throughput in vitro cell-based characterization.We are seeking a Scientist who is expected to execute preclinical scientific studies, and demonstrates willingness to learn to lead and design these studies, with the goal of generating and testing new vaccine candidates. We are looking for a highly motivated scientist, with the willingness to learn the most up to date molecular biology and cell biology techniques in a high-throughput environment.This role will report directly to the RNA Research and Rapid Response Lab Head and will play a significant role in executing high profile projects allowing for substantial exposure to cross functional teams working within the RNA vaccines CoE matrix team, and to the senior leadership.Key Responsibilities:

• Execute and analyze scientific studies to generate and test new vaccine candidates
• Demonstrate competency in the areas of DNA cloning, in vitro RNA transcription and cell-based assay characterization of vaccine candidates, with special emphasis on large scale in vitro RNA transcription
• Learn and execute high-throughput workflows for molecular biology and cell biology processes to generate and characterize vaccine candidates
• Work with other scientists to design and develop new assays and technologies to support RNA vaccine generation and evaluationBasic Qualifications:
  • PhD degree in life sciences with 0+ years of experience in a related biotechnology field or Master with at least 2 years of experience in a related biotechnology field
  • One or more years of experience in molecular biology and cloning, including gibson assembly, golden gate assembly mutagenesis, as well as RNA production and purification, and tissue culture proficiency.
  • One or more years of experience with common molecular biology software, e.g. Geneious, and adept at analyzing large volumes of sequencing dataPreferred Qualifications:
    • Experience in high-throughput RNA in vitro transcription techniques and familiarity with RNA based vaccine technology
      • Comfortable with in vitro cell-based assays to evaluate vaccine candidates, for example FACS analysis or High-Content Imaging#Vx-Cam#Li-GSKPlease visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

Keywords: Disability Solutions, Manchester , Scientist, Large Scale RNA Production, Professions , Cambridge, New Hampshire